Ask the Experts

What Can You Tell Me About Vyvanse?

“What can you tell me about Vyvanse, the new stimulant medication?”

Vyvanse (lisdexamfetamine dimesylate) is known as a “prodrug,” meaning that it is chemically inert until it interacts with an amino acid in the gastrointestinal tract. Unlike conventional stimulants, it has no noticeable mood-altering effect if it’s crushed and snorted or injected. That suggests that it will have a lower potential for abuse. Even so, the FDA will probably classify Vyvanse as a controlled substance, like conventional stimulants. It is designed for once-daily dosing, with efficacy and side effects comparable to those of Adderall XR.

Vyvanse, which is manufactured by Shire Pharmaceuticals, went on sale in the summer of 2007.

Updated on April 6, 2018

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  1. This month I had a pharmacist at Walmart tell me that people CAN ‘get high’ by “snorting and crushing, injecting Vyvanse”. I’ve been telling my patients that it is a safer alternative formulation, basically the information Dr. Larry Silver has stated in this article. Has this changed? I did notice that Northpoint Washington has a blog on their addictions website that speaks to the abuse of Vyvanse by athletes and recreational abusers. While Vyvanse isn’t perfect, up till now I’ve thought it was a good option for my former addicts who have severe ADHD, or children with parents who have this history.

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