Ask the Experts

Switching to Stimulants

“I’ve been taking antidepressants for several years and am currently on Wellbutrin. Now my doctor says I have ADHD and wants me to go off the Wellbutrin and start taking a stimulant. How do I go about making the switch?”

Stimulants start working within an hour of ingestion and are eliminated from the body by the end of the specified duration (four hours, 12 hours, and so on).

In contrast, antidepressants can take weeks to build up to effective levels. If you decide to stop taking one, the dosage must be reduced gradually.

The length of time you’ll need to taper off the Wellbutrin depends on how much you’ve been taking and how long you’ve been taking it. In general, it’s safe to start taking a stimulant immediately, even during this transition period.