Medication and Treatment Reviews


Generic Name: Guanfacine


Intuniv, known as guanfacine in its generic forum, is a once-daily, non-stimulant medication used to treat ADHD in children ages 6-12, adolescents, and adults. It is commonly used as a monotherapy, or as a complementary treatment alongside stimulant medications.

Intuniv is a central alpha2A-adrenergic receptor agonist that is thought to affect receptors in the brain in a way that helps symptoms of ADHD such as emotional sensitivity, hyperarousal, and social aggression. Non-stimulant medications like Intuniv sometimes help patients with ADHD who can’t take or don’t experience benefits from stimulants.

Intuniv has not been studied in children younger than 6. Intuniv does not have a high risk of abuse or dependence. It is not a controlled substance.

The immediate-release formulation of guanfacine is used to treat high-blood pressure.

How to Use Intuniv

Before starting or refilling an Intuniv prescription, read the medication guide included with your pills, as it may be updated with new information.

This guide should not replace a conversation with your doctor, who has a holistic view of your or your child’s medical history, other diagnoses, and other prescriptions. If you have questions, ask your doctor or pharmacist before you begin taking the medication.


As with all medications, follow your Intuniv prescription instructions exactly. Intuniv is an extended-release tablet taken once daily in the morning or evening at approximately the same time each day. Tablets are available in 1mg, 2mg, 3mg, and 4mg dosages.

Intuniv should not be taken with a high-fat meal. This can speed up the release of medication, and increase the risk of side effects. Tablets should be swallowed whole, and never crushed or chewed.

The optimal dosage varies patient by patient. Your doctor may adjust your dosage weekly by 1mg increments until you or your child experiences the best response — that is, the lowest dosage at which you experience the greatest improvement in symptoms without side effects.

If you miss a dose, you should take it as soon as possible, unless it is already time for your next dose. You should not take two doses of Intuniv at the same time. Contact your doctor if you have questions about skipped pills.

Do not drink alcohol while taking this drug.

When discontinuing treatment, or decreasing dosage, patients should work with a doctor to gradually taper the level of medication by no more than 1mg every 3 to 7 days. Stopping Intuniv suddenly can create withdrawal symptoms including increased heart rate and high blood pressure, sometimes accompanied by headaches, confusion, agitation, or tremors.

Side Effects

The most common side effects of Intuniv are as follows: sedation, tiredness, difficulty sleeping, low blood pressure, nausea, stomach pain, dizziness, dry mouth, irritability, vomiting, and slow heart rate.

Other serious side effects include low blood pressure or heart rate, fainting, sleepiness, or withdrawal symptoms. Taking Intuniv may impair your or your teenager’s ability to drive, operate machinery, or perform other potentially dangerous tasks. If side effects are bothersome, or do not go away, talk to your doctor. Most people taking this medication do not experience any of these side effects.

Report to your doctor any heart-related problems or a family history of heart and blood pressure problems. Patients with structural cardiac abnormalities, renal failure, and serious heart problems could experience complications while taking Intuniv. Physicians should monitor these vital signs closely during treatment. Call your doctor immediately if you or your child experience warning signs such as chest pain, shortness of breath, or fainting while taking Intuniv.

The above is not a complete list of potential side effects. If you notice any health changes not listed above, discuss them with your doctor or pharmacist.

Precautions and Safety

Store Intuniv in a secure place out of the reach of children, and at room temperature. Do not share your Intuniv prescription with anyone, even another person with ADHD. Sharing prescription medication is illegal, and can cause harm.

You should not take Intuniv if you have an allergy to Intuniv or any of its ingredients. You should use caution taking Intuniv if you have kidney problems, a history of fainting, heart problems, or a history of stroke.

Avoid becoming overheated or dehydrated while taking Intuniv.

If you’re thinking of becoming pregnant, discuss the use of Intuniv with your doctor. Animal studies indicate a potential risk of fetal harm. It is not known if Intuniv is passed through breastmilk, so it is recommended that mothers do not nurse while taking it.


Before taking Intuniv, discuss all other active prescription medications with your doctor. Intuniv can exacerbate the drowsiness created by depressants including alcohol, barbiturates, antihistamines, or other sedatives.

Share a list of all vitamin or herbal supplements, and prescription and non-prescription medications you take with the pharmacist when you fill your prescription, and let all doctors and physicians know you are taking Intuniv before having any surgery or laboratory tests. The above is not a complete list of all possible drug interactions.



16 reviews

  1. My 7-year-old son has been on 36 mg Concerta since March. It has been very good for him. He had also been taking 3 mg Intuniv up until April. I found that it lasted all day and into the night. We began a very slow taper off. We slowly noticed a facial tic as we ended the Intuniv. When we finally stopped the tic became much worse.

  2. My son is 16 and has been taking ADHD medication for several years. He now takes Focalin XR and added Intuniv about a year ago. He is doing better with his attention, but doesn’t like the way the meds make him feel. He feels like it dulls his “fun” personality. Without the meds, he is very hyper, but likes to joke and cut up with his friends. When he is taking his medicine, he is quieter but easily annoyed and angered.

  3. My 10-year-old started on 1mg Intuniv 7 days ago, so will be starting the 2nd week trial at 2mg. He has been more tired. The 3rd day headaches started, which have not lessened.

  4. I have a teenage son that just started Intuniv and is on 2mg at this time. He is taking Intuniv in place of a stimulant due to anxiety. His side effects are light-headedness upon standing too quickly and tingling of his extremities.

  5. My son was very sleepy when he started taking it. He only takes 2mg dosage between dinner and bedtime. He is still sleepy towards the end of the evenings. We are having good results in school and at home.

  6. We switched our 17 years old son from Concerta to Intuniv one month ago. He started on 1mg and then after a week went to 2 mg. He has been doing really well on the 2mg, so we don’t feel the need to go up to 3mg. Concerta was making him have horrific nightmares and he had no appetite. Since being on Intuniv, he is eating like a normal 17 years old. He has gained 5 lbs. this month and he is sleeping well and no nightmares. Only side effect was being really tired at the beginning but that has worn off.

  7. Tenex (the short-acting form of Intuniv) was added to my daughter’s mix of medications a few months ago. She is almost 11 and, clearly, takes other meds – so our experience may be less relevant than that of others. However, it has been a welcome addition. We have never had a ‘eureka’ moment with her meds but the Tenex seems to help her very much with impulse control.

  8. Our 10 years old began 2ml of short-acting Intuniv 2x/day (Guanfacine, Tenex) and continued taking it for 3.5 months. This medicine triggered the most bizarre behavior – mania, aggression, and illness. It “cured” the hyperactivity almost overnight, but it did nothing for the inattentiveness.

  9. My 9 year-old son started Intuniv about a month ago. He also takes Vyvanse. We have seen a big difference in impulsive behavior. The two weeks he had some lethargy, but his body has adjusted and he no longer has that tired feeling.

  10. My son took Intuniv with his stimulant for about 9 months a couple years ago. We finally realized his new nightmares were the Intuniv and they went away within a couple days of stopping it.

  11. My 17-year-old ADHD son is on his 4th week of Intuniv (the 2nd week of 3 mgs) & he still seems very tired. He takes it in the morning with the lowest dose of Vyvanse. He does also seem irritable a lot.

  12. One of my twin daughters (age 8-1/2) takes Guanfacine. She was started on it when she had too much of a bounce-back effect from Ritalin and then Adderall (being angry and frustrated when the meds wore off). Guanfacine definitely helped her, but it is too short acting to get her through the day. She now takes Strattera in the morning, 1/2 mg. of Guanfacine mid-afternoon, and 2 mg. Intuniv plus 25 mg. Trazadone before bed.

  13. My son is almost 6 years old and he takes Methylphenidate 10mg in the morning and Intuniv 3 mg at night. My son is a total different person with this medication. He is much less moody and has less mood swings and is much less aggressive towards others. However, I must say that if he misses one dose, all hell breaks loose.

  14. My 13-year-old son takes Concerta daily in the morning and takes Intuniv at night with dinner. He has not experienced any of the side effects. I found that the Intuniv helps with the impulsivity and frustration, too.

  15. I’m 55 years old, and have been on Intuniv for a few months now. I was hoping it would help with impulsivity. I started on 1 mg, working up to 4 mg daily (morning), and took this along with Adderall (usually 10 mg daily). I found myself in rages a few times (actually threw a glass at one point),more scattered and acting haphazardly, and also extremely tired. So, I’ve cut all the way back to the 1 mg daily dosage, and feel much better. I also stopped the Adderall, since I’ve realized it’s caused excessive hair loss.

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