ADHD Medication and Treatment Reviews


Generic Name: Dextroamphetamine sulfate

What is Dexedrine?

Dexedrine (generic name: dextroamphetamine sulfate) is a long- or short-acting capsule, taken orally, that is primarily used to treat attention deficit hyperactivity disorder (ADHD) in children ages 3-12, adolescents, and adults. According to the US. Food and Drug Administration (FDA), Dexedrine is a federally controlled substance (CII) because it can be abused or lead to dependence. It is an amphetamine.

Dexedrine may improve focus and decrease impulsivity and hyperactive behavior, two hallmark symptoms for some patients with ADHD.

The American Academy of Pediatrics (AAP) recommends treatment with behavioral therapy before medication for children under the age of 6. For children ages 6 to 11, the AAP says “The primary care clinician should prescribe US Food and Drug Administration–approved medications for ADHD and/or evidence-based parent- and/or teacher-administered behavior therapy as treatment for ADHD, preferably both.” Likewise, the National Institute of Mental Health finds the most successful treatment plans use a combination of ADHD medication, like Dexedrine, and behavior therapies.

Dexedrine is also used to treat narcolepsy.

How to Use Dexedrine

Before starting or refilling a Dexedrine prescription, read the medication guide included with your pills, as it may be updated with new information.

This guide should not replace a conversation with your doctor, who has a holistic view of your or your child’s medical history, other diagnoses, and other prescriptions. If you have questions, ask your doctor or pharmacist before you begin taking the medication.

Dosage for Dexedrine

As with all medications, follow your Dexedrine prescription instructions exactly. Short-acting Dexedrine tablets are taken two to three times daily. The tablets are available in 5mg doses. The first dose is typically taken first thing in the morning; tablets should be taken at the same time each day for the best results. The long-acting Dexedrine capsule is taken once daily, in the morning. 5 mg, 10 mg, and 15 mg doses are available. The time-release formulation is designed to maintain a steady level of medication in your body throughout the day.

The optimal dosage varies widely by patient; it is not determined by age, weight, or height, but rather by how a person metabolizes the medication.

During treatment, your doctor may periodically ask you to stop taking your Dexedrine so that he or she can monitor ADHD symptoms; check vital statistics including blood, heart, and blood pressure; or evaluate height and weight. If any problems are found, your doctor may recommend discontinuing treatment.

Some patients report developing a tolerance to Dexedrine after long-term usage. If you notice that your dosage is no longer controlling your symptoms, talk to your doctor to plan a course of action.

Side Effects Associated with Dexedrine

The most common side effects of Dexedrine are as follows: irregular heartbeat, decreased appetite, tremors, headache, sleep disruptions, dizziness, stomach upset, weight loss, and dry mouth.

Other serious side effects include: slowed growth in children, seizures, and changes in eyesight. Dexedrine may impair your or your teenager’s ability to drive, operate machinery, or perform other potentially dangerous tasks. This side effect usually wears off with time. If side effects are bothersome, or do not go away, talk to your doctor. Most people taking this medication do not experience any of these side effects.

Report to your doctor any heart-related problems or a family history of heart and blood pressure problems. Patients with structural cardiac abnormalities and other serious heart problems have experienced sudden death, stroke, heart attack, and increased blood pressure while taking Dexedrine. Amphetamines can increase blood pressure and heart rate. Physicians should monitor these vital signs closely during treatment. Call your doctor immediately if you or your child experiences warning signs such as chest pain, shortness of breath, or fainting while taking Dexedrine.

Also disclose to your physician all mental health issues including any family history of suicide, bipolar illness, tics, or depression. The FDA recommends evaluating patients for bipolar disorder, tics, and Tourette’s syndrome prior to stimulant administration. Dexedrine may create new or exacerbate existing behavior problems, bipolar illness, or Tourette’s syndrome. It can cause psychotic or manic symptoms in children and teenagers. Call your doctor immediately if you or your child experiences new or worsening mental health symptoms including hallucinations or sudden suspicions.

Discuss circulation problems with your doctor before taking Dexedrine, which has been known to cause numbness, coolness, or pain in fingers or toes, including Raynaud’s phenomenon. Report to your doctor any new blood-flow problems, pain, skin color changes, or sensitivities to temperature while taking Dexedrine.

Amphetamines like Dexedrine have a high potential for abuse and addiction, especially among people who do not have ADHD. It is a “Schedule II Stimulant,” a designation that the Drug Enforcement Agency uses for drugs with a high potential for abuse. Other Schedule II drugs include Adderall, Ritalin, and cocaine. People with a history of drug abuse should use caution when trying this medication. Taking the medication exactly as prescribed can reduce potential for abuse.

The above is not a complete list of potential side effects. If you notice any health changes not listed above, discuss them with your doctor or pharmacist.

Precautions Associated with Dexedrine

Store Dexedrine in a secure place out of the reach of children, and at room temperature. Do not share your Dexedrine prescription with anyone, even another person with ADHD. Sharing prescription medication is illegal, and can cause harm.

You should not take Dexedrine if you:

  • Have an existing heart condition or hardening of the arteries
  • Have high blood pressure
  • Have glaucoma
  • Are very anxious, tense, or agitated
  • Have a history of drug or alcohol abuse
  • Have taken a monoamine oxidase inhibitor (MAOI) within 14 days
  • Have an allergy to amphetamines, other stimulant medications, or other ingredients in Dexedrine

You should use caution taking Dexedrine if you have mental problems, tics or Tourette’s syndrome, thyroid problems, seizures, or circulation problems.

If you’re thinking of becoming pregnant, discuss the use of Dexedrine with your doctor. Animal studies indicate a potential risk of fetal harm. Dexedrine is passed through breastmilk, so it is recommended that mothers do not nurse while taking it.

Interactions Associated with Dexedrine

Before taking Dexedrine, discuss all other active prescription medications with your doctor. Dexedrine can have a dangerous, possibly fatal, interaction with antidepressants including MAOIs.

Exercise caution with medicines that are known to interact with amphetamines including lithium, seizure medications, blood pressure medications, stomach acid medications — like antacids — and cold or allergy medicines that contain decongestants. Even over-the-counter medications may contain ingredients that raise or lower the level of the medication in your blood to a dangerous level. Speak with your doctor about all other prescription and over-the-counter medications you take.

Share a list of all vitamin or herbal supplements, and prescription and non-prescription medications you take with the pharmacist when you fill your prescription, and let all doctors and physicians know you are taking Dexedrine before having any surgery or laboratory tests. The above is not a complete list of all possible drug interactions.


24 Dexedrine Related Links

  1. Thanks to a very supportive and open minded general practitioner I was finally diagnosed with ADD about six months ago (age 32). So, I’m early on in my ADD journey, and late at the same time!

    Initially I was prescribed Strattera (Atomoxetine) and it changed my life for the better. But it was extremely expensive and because of my age I wasn’t eligible for a subsidised script. My psychiatrist gave me a script for Dex instead because it would be more affordable.

    As it turns out I have had even better results from Dexedrine. I take it twice a day (total of 15-20mg during the day). My dose depends on my day. I work full time in an office environment and study part time so when I have lots of meetings or an assignment due I vary the dose (my psychiatrist has approved this). I find that I can reduce my dose to 5-10mg for one day without any problems, but if I do that more than one day I start to feel fatigued and the ADD symptoms ramp up.

    My sleep is still good as long as I am mindful about when I take my afternoon dose (no later that 2pm) and I wake up feeling more rested than I did before I started using this medication. My heart rate has increased so I had an ECG but it’s all fine.

    The biggest problem for me is loss of appetite. I have been working with a dietitian to make sure that I am getting adequate nutrition and don’t revert to disordered eating. It’s difficult to make sure I am eating regularly, so I’ve started using an app to remind me at regular intervals that it’s time to go get something.

  2. I began taking Dextroamphetamine Sulfate at age 9, starting with 5mg XR once daily and I am now 18 and take 20mg XR twice daily as well as a regular 10mg in the afternoon. Until I was about 16, this medication worked wonders on me. Before taking it, and when I do not take it, I grow irritated and irrational very fast, lack motivation, self-esteem, and focus. I currently take the two 20mg XR capsules when I wake up for classes around 8:30, and take the 10mg regular around 3 PM, however, I have noticed that even with the dosage increases, it is doing less and less for me, at this point it really only keeps me from getting irritated and irrational, I understand that ADD/ADHD medications are not miracle pills, and I still need to contribute, but lacking focus has lowered my self-esteem.

    An example of me lacking focus: I took the 20mg XRs about 4 hours ago (no morning classes) and I am currently supposed to be writing a paper for my Chemistry class, however, I got distracted and am now writing this instead. I plan to talk to my doctor about switching off of an amphetamine-based medication and switching to a methylphenidate-based one as I feel I have built a tolerance up for amphetamines.

    Side note: For a while the Pharmacy I use did not have Dexedrine, so they gave me Adderall as it is an approved substitute, and I actually had no idea that they had done this, as my dad had picked up the prescription, however, I felt as if it worked a whole lot better, so when I found out it was Adderall, I wanted to switch, but insurance wanted me to have the generic if available, and the generic for Adderall and Dexedrine is pretty much the same exact thing (if not the same, I’m not 100% sure).

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