Methylphenidate manufacturer changed and it doesn’t seem to work as well.

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This topic contains 33 replies, has 20 voices, and was last updated by  mbattista 4 months ago.

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  • #85258

    AndieBaer
    Participant

    It could be the end of the school year craziness and other issues, but my son’s methylphenidate doesn’t seem to be as effective as it used to be. My pharmacist said the manufacturer changed recently, but it would be only a 5 percent difference between those generics and it would not be the cause of the behavior issues. I am working on other solutions for him, but I am curious if anyone else has had a similar experience when a generic med mfg changed.

    • This topic was modified 1 year, 6 months ago by  AndieBaer.
  • #85289

    Penny Williams
    Keymaster

    Many generic stimulants do not work the same as the brand name. For instance, Concerta has a unique time-release mechanism. Most of the generics (except Actavis) don’t use this mechanism that makes Concerta work the way it does. Several were so bad that the FDA pulled their generic equivalency status. Now, sadly, there are new ones on the market that I hear are just as bad. I personally drive out of my way to Walgreens each month because their policy is to carry the good generic and CVS is only using the newest (cheapest) one.

    Generic Concerta Is Not Created Equal

    Penny
    ADDitude Community Moderator, Parenting ADHD Trainer & Author, Mom to teen w/ ADHD, LDs, and autism

    • #111657

      cperg51018
      Participant

      Well you have found another kvk victim. My pharmacy changed vendors two month’s ago from Actavis the prior month’s. What a difference. I just about want to stop taking the medication because of how it makes me feel. I am up front with my pharmacist and told him that I cannot quite put my thumb on it but I will. I have notified KVK and Quality control are suppose to be in contact with me. I have been through Accelerated One year Medical Assistant school. 76 hour’s in one year. I held between a 3.80-4.0 GPA. Was on the dean’s list wrote a paper on MS. It was so good the board put it in there Archives, If it was not for Ritalin at the time there is no way I would have been able to hold the GPA I did. I do have a problem with generic’s, How can so many companie’s manufacture this product and be the same, Wouldn’t you call that PATENT infringement. Also what are the FAA guidelines to this. I happen to be very qualified in the medical world but I keep my self distant until need be.I do not like GOD SYNDROME. I know all are looking to save money but at what cost.This medication I say is a considered a Maintenance medication, You know you are taking it physically and that’s it. Not KVK I feel like I am on Drug’s. Sorry for putting it that way but it’s the only way I can describe.If any other input is wanted please E-mail me. This blog hit it right on the head and Thank you for that. Curtis.P.

    • #122556

      jj1234567
      Participant

      Same thing here! So annoyed!

    • #122560

      jj1234567
      Participant

      My local Walgreens used to carry the name brand as well but not anymore.

    • #122669

      vrwalden
      Participant

      It is not just Ritalin and their generic. Our insurance company through husbands work and they won’t cover generic adderal but they will cover the real stuff but it doesn’t seem to be working or my son out grew it and he is on max dose. This is my second child with ADHD/ODD. This child also has several learning disabilities. There have been some really rough days lately. He fusses about everything and sticks his nose on adult conversations and argue about things he knows nothing about. 24 yr old called the other day and we compared his symptoms to his brothers. He suggested therapy, he would know he had the same issues so sort of talking to the source so to speak.

  • #85305

    staceystanford4
    Participant

    I had the exact same problem at the end of the year! I thought it was just the end of the school year nerves and excitement but now I wonder!

  • #85313

    staceystanford4
    Participant

    Who is the manufacturer of the Methylphenidate that doesn’t work and of the one that does work?
    Stacey

    • #122557

      jj1234567
      Participant

      Activis who sold to Teva or Mallinkroft Inc. are only effective brands I’ve found. I called Activis now Teva pharmaceuticals and told “sorry we stopped manufacturing IR methylphenidate”. Mallinkroft still manufactures but every big chain pharmacy refuses to order and replaced with cheap generic horrible brand (s). Even though doctor writes on prescription to fill only with name brand they refuse to order it.

  • #85343

    AndieBaer
    Participant

    Old manufacturer that worked ok: Actavis
    New manufacturer that may not be working as well: KVK

  • #85326

    JBoom
    Participant

    This is a common problem, as I discovered recently when my pharmacy changed to a different generic Adderal. It was not as effective at all and made me very moody. I talked with the pharmacist about it. He said they don’t take special order for generic brands for narcotics, but if my doctor specifies “Brand name only” on the prescription, that would at least be more consistent.

    That’s what I did, problem solved. However, this solution will depend on your insurance policy.

    Here’s another article about it on this site:

    Name-Brand Prescriptions vs. Generic Drugs

  • #85375

    Penny Williams
    Keymaster

    Jannsen and Actavis are both true equivalents.

    These are the 3 new manufacturers and it looks like none of them use the unique osmotic mechanism of Concerta:

    Trigen, Mylan, Impax

    Penny
    ADDitude Community Moderator, Parenting ADHD Trainer & Author, Mom to teen w/ ADHD, LDs, and autism

  • #85658

    AndieBaer
    Participant

    Thanks to those of you who replied to my post. We are able to find another pharmacy and get the Activas methylphenidate. It will be difficult to tell though if it was the mfg change or other factors affecting his behavior. Worth the effort though, even if it only helps a little! 🙂

  • #116450

    Cooper
    Participant

    I was taking Concerta 18mg ER, and due to insurance issues was changed to Methylphenidate 20mg ER, manufactured by Mallinckrodt; and Methylphenidate 5mg, manufactured by KVK. I feel like I’m on a placebo! They do nothing for my ADHD, and I have constant diarrhea, stomach cramps and dehydration. I thought I was losing my mind. My insurance company will not cover Concerta OR the Generic version at a reasonable rate. Very sad that the FDA lets this stuff happen.

  • #116680

    PaulS
    Participant

    I’ve experienced HUGE differences between various generic brands of methylphenidate – and I only take the instant release (IR). It is amazing how different they are. It’s also very hard to get a pharmacy to stick with a particular generic – or even tell you which they have in stock. I will probably switch to the brand name.

    Details: I don’t take Concerta, but just IR methylphenidate. I was taking the Actavis generic 10mg for years with great results. I tried switching pharmacies once and got a different generic and it felt like a placebo – Copharma? Back on Actavis all good. Then the pharmacy switched to KVK and it was much less effective. I asked the pharmacy to change back, but they say they have no control over what is sent to them. I got used to it, but always wondered if maybe I was over-reacting. It seemed I needed maybe 25-50% more drug and it never worked as well. Suddenly, they changed back to Actavis and all was good for a few month – much better. Then it was back to KVK, then it was random – KVK for a month, then Actavis, then KVK, and now an IR from Mallinckdodt, which is causing headaches and feels like it does nothing.

    I am amazed at the differences. I hate to blame the medicine, but I’ve missed some deadlines at work and hate not being able to predict how I will feel or how I will function at work or home.

    All this is just for the IR. From what I’ve read, the extended release versions are even more problematic, as they can have different effects when the drug is in your system – but the chemical release mechanisms are totally different as well. A few years ago the FDA ruled they were not equivalent.

    I did find after a few months on the KVK, it was better – so if I could consistently get that at 1/2 the price of the brand, I probably would – but this constant changing is intolerable, so brand name for me if I can get that to work.

    • #122558

      jj1234567
      Participant

      Nailed that right on head. I’m going through same exact thing for months.

  • #116877

    KVKTECHVictim
    Participant

    KVK Tech is a heinous methylphenidate manufacturer. I don’t know what they are doing, how much they are profiting by the subpar corners they are cutting but it is heinous! And CVS is killing us by almost exclusively using this horrific company. It is as if I took a street drug that was laced with rat poison, and I have been taking methylphenidate for 20 years without a problem until KVK Tech became the cheapest maker of this ADD medicine, and thus CVS jumped at the the opportunity. They don’t care. The quality is just heinous.

    • #122555

      jj1234567
      Participant

      Glad I’m not the only one going thru this. I totally agree. Cvs is the worst place matter a fact all the “big name” pharmacies have all gone to the cheapest, non effective crap generic brand and there’s more than one out there now that activis/Teva stopped making IR methylphenidate. Over the 8 years I’ve had no issues getting either mallinkroft or activis/teva brand meds up until 2019. New yellow tablets are garbage, non effective not to mention gives migraines. I don’t understand why when my doctor specifically writes on the prescription “fill only with name brand” that CVS, RITEAID, WALMART, and many local privately owned pharmacies refuse to order/follow a doctors order but that is what I’ve been dealing with for months. Last I checked pharmacies aren’t MD’s their job is to fill/follow a doctor’s order/script I thought anyway. I pay A LOT of money every month for my health insurance coverage not to mention the copays for meds, dr. visit etc. as a patient I gave every right to call and ask what brand each pharmacy has yet when doing so I get attitude from 9 outta 10 pharmacies. I’m not trying to fill early ever nothing shady at all and I’m not calling about a heavy duty opiate so not sure why I’m being treated the way I have been. Walmart refuses to even tell you what brand they have! That’s just ridiculous.

  • #117071

    thanbaisunwin
    Participant

    Thanks !

  • #121957

    SteveB
    Participant

    I’m really glad I found this thread. I was prescribed methylphenidate for ADD diagnosis, my first prescription I had filled at Walgreens. They didn’t accept my insurance so I paid out of pocket because it was only $25. I had a positive experience with the medication so I went to the Dr and got a new prescription. This time I went to CVS because they accept my insurance. The first thing I noticed was that the pills physically looked different, but I didn’t think anything of it at all. On the first day with the medication I thought maybe I received a placebo because I didn’t feel any effects at all. But after nearly a week of taking this stuff I can tell you it is NOT the same as my previous batch. The effects aren’t really there, and I have side effects I didn’t have. I feel slow and tired, abdominal pain, etc. It’s not the same medication. This stuff is awful. After reading this thread I know now that I’m not imagining things. I called the CVS I received this from and they claim that I can return it and transfer my prescription elsewhere. I will go over there and see if this is the case because I really hate to waste a prescription.

    • #121975

      SteveB
      Participant

      I was misinformed over the phone. CVS can’t take back the medication. Best I can do is keep taking it and hope it gets better or wait until next month when I can get a new prescription and have it filled somewhere else.

    • #122559

      jj1234567
      Participant

      I’m in same boat and couldn’t agree with you more but be careful switching pharmacies cause I’m finding they all have switched to cheapest generic available. Hey I get it they are a business they want to make most money they can but when (going by what I’ve just read online on many sites) the new generic is garbage then they should be doing something about it.

  • #122044

    Deep
    Participant

    A more detailed description of, and research into, Concerta (methylphenidate) differences has been made by Gina Pera at adhdrollercoaster.org: https://adhdrollercoaster.org/medication/authorized-generic-concerta-update-6-1-19/

  • #122584

    edge1
    Participant

    Same thing with me. I do not feel the affects as I did with other brands and the little that I feel does not last long. I called KVK and made a complaint today see it anything happens.

  • #123317

    Zzztami
    Participant

    I thought i was the ONLY one…. kvk and Northstar do NOT work the same as the ones ive been getting for years! Northstar is the worst… it’s also the cheapest. It’s not fun calling around to different pharmacys asking which manufacturer do you get your methylphenidate from?

  • #123318

    vrwalden
    Participant

    Hey everyone, so my husbands new insurance won’t cover the generic unless the doctor jumps through their hoops and then we have to pay the higher copay my son takes two scripts at $50 a whack that is $100 bucks a month for his meds. So we changed to name brand adderal because they will cover that one at the lower copay which is $35 a whack so $70 a month. And the name brand is not working at all. So long story short we are waiting to go to the dr until the 31 because of pay day and copays for specialist of $60. Meanwhile, he is out of afternoon meds, so I went in the reserve bathroom stash of extra meds because of our pharmacy over filling meds and child simply not taking them. Anyway gave him a generic for the afternoon and you would not believe the difference, a good day for a change. Now we wait three more days for dr app and see what he thinks and I am going to have him look at these posts when I go to see him. Maybe I can get him to post for advice, for others. Between the insurance, the drug companies, and the dr office I am stressed out to the max. He has been on vacation with us to the beach, a week to church camp, and 7 weeks of SWAT-Strength Weight Agility Training, Now we start football camp for a week and school starts the 15th of Aug.

    For the person that complained about CVS not taking the meds back. Our pharmacy won’t take it back once it comes out the window and into the car, that is why you are to look at the thing to sign and if it is correct sign and then get meds, I hate that they stick my debit card in the bag, cuz one I threw away my Flex card (HSA Benefits).

  • #123398

    edge1
    Participant

    heard back from KVK quality control today and they are investigating the matter and asked that I send them 2 tablets of the medication. Glad to see they are following through. I asked if there were any similar complaints they said no so maybe we can all contact them and express our concern about this and get it resolved.

    • #123409

      vrwalden
      Participant

      My sons meds are capsules not tablets and they are not working but are having the opposite problem the generic works better than the name brand

  • #123412

    BlackADDer
    Participant

    I can only find two suppliers of these medications in my country; Novatis (for Ritalin) and Jannsen-Cilag (for Concerta).

    This apparent lack of choice is deceptive as the mechanism involved keeps the costs of all vital pharmaceuticals to a minimum for the patient.

    I have a regular supply of a 100 x 10ml Ritalin. The maximum I can be charged for it is $29.50 AUD. For higher doses the maximum cost is $40.30 AUD.

    If I was a pensioner or on a government benefit, I would only pay the same for any prescription I receive from a GP; $6.50. I do not have to shop around as that is the same for all pharmacies everywhere. But the option of obtaining a supply from a bordering country is zero, there are none.

  • #124087

    dreanah
    Participant

    My son is taking this and we have noticed a change as well. I had to stop him from taking it because he was experiencing some type of feeling of something touching his body, not wanting to be alone and saying he is afraid. Now that school will start for him soon, he will definitely need some type of medication. It has been Very hard for us the past couple of weeks without him taking anything. He has a doctor’s appointment today so hopefully she will have another solution.

  • #124095

    edge1
    Participant

    I went to my doctor today and explained everything. From now on she is writing for the brand and said that I am not the only one.

  • #124214

    AutumnDraidean
    Participant

    So I tried calling around in my local area and learned, to my general dismay, that a lot of pharmacies cannot tell you how much an Rx will cost until they actually have the Rx. They have to tell you the cash price(in NYS) and GoodRx may only be a little less. They were, with one exception, willing to tell me who’s generic they were buying but warned me that this could change at any point.

    Walmart/Sams has a policy that they will absolutely not tell you which manufacturer they are currently buying from!

    I am waiting to borrow the book

      Bottle of Lies

    I’ve read snippits of it in the bookstore. I also sent a message to NYS Attorney Generals office detailing my concerns. The whole thing where they won’t tell you the insurance price without the Rx being sent to them is the part I’m hottest about. As I understand, you can’t move a controlled substance Rx between pharmacies, you have to call your doctors office and we all know how easy that often isn’t!

  • #124520

    ElleK
    Participant

    I had a difficult time with the switch from Sandoz manufacturer of methylphenidate 10mg to other generics. They either were like placebos or placebos with added side effects . I asked my doctor about switching to the brand name, but she really wanted me to try Concerta instead of immediate release Ritalin. I had a terrible reaction to the Concerta (it was a generic) I had waves of chills, nausea, a headache and my hands and feet turned to ice, that continued for the entire day about every 30 minutes. She said she didn’t know of that happening to anyone else but agreed to switch me to Ritalin 10mg. Turns out Concerta generics, while FDA approved–the delivery method is still patented so even though the medication is supposed to be the same, how it is released throughout the day may not be. Perhaps I am more sensitive than most, but I noticed a positive change with the Ritalin brand name. I am surprised that it was under 30 AUD!! I pay $97 every 30 days, (10mg/ 90 pills) as my insurance will only cover generics. That is with the goodrx coupon discount. Even though I wished it worked better, and my doc has been trying to get me to be open to Adderall I’m concerned about side effects, and also cost–Adderall is more than 2x the cost of Ritalin and after battling CVS over useless generics for the past couple of years I stopped taking methylphenidate for a year. But that was a mistake. I definitely notice Ritalin is more consistent and I need less of it. I do need to take more as I get close to my monthly cycle when hormones are changing though.

  • #125167

    mbattista
    Participant

    So as I write this, I have been up with my son all night who can’t sleep due to the change in his meds because of manufacturer changing. Two months ago, I changed from Walgreens to CVS because it was closer to my house because we moved and I noticed his meds were different looking but thought nothing of it. He is on Concerta and other meds were great. With in a week, noticed such a change…like he wasn’t on anything at all. Not sleeping, afraid of everything, so hyper, moody, such a huge change. Gave it time but that not sleeping became a huge problem. Called his doctor to see if I was crazy noticing a change, called CVS, went to Walgreens and finally someone told me could be the change in manufacturing. I couldn’t keep giving to him because it was horrible…but I had to. Finally I called insurance company and they were so nicely to change date of next refill and I went back to Walgreens and got what he was on before! Yay…and last month great. Now last week went to pick up his perscription, and Walgreens changed manufacturer and I want to cry. Happening all over again:( He was on other meds for a year and it has been so great and now this again. I went back to Walgreens right after I noticed meds different looking last week and she said yes they changed and to come back if I see a change and see what they can do and if can go back and I hate to do that…but I have to go back and ask again. It is so horrible and I get they need to do this, but it’s so hard on my son when he is use to one thing and I can’t keep him on it. School is starting soon and I need him on the ones he has been use to for a year. I can’t have him not sleeping and everything else. It’s so frustrating and I feel terrible for him:( this blog has helped so much because I seriously thought I was crazy this was happening so thank you for that.

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