Evening Horrible ADHD problems

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    • #81419

      Hi all who choose to read this. I am experiencing quite drastic ADHD symptoms (both hyperactivity and inattentive) around the evening hours. I’m considering actually doing what my doctor said and stopping my ADHD medicine, because after it is done in my system early in the day the rest of the day the focus is actually made tremendously worse for me, so I really have to be careful with stimulants. I’m also taking Zoloft 150 mg currently, which is way too much SSRI for me to handle, but my doctor keeps telling me it helps with my anxiety (which I agree with but it’s sabotaging my focus so bad that I cannot get any homework done and I literally have to almost tie myself down to not want to move and stay on task). It’s gotten so bad in the evenings and now it’s progressing into the afternoons as well and the medicines seem to progressively make my ADHD worse over time the longer I’m on them. I am slowly tapering myself off, as I just want to avoid withdrawal (with dexedrine), but I’m honestly upset that I ever got put on zoloft+dexedrine together because I’ve spent a whole semester thinking this was as good as it gets for my ADHD (1-2) hours of productivity a day that I was just in denial I guess because I didn’t realize that what was supposed to be helping me just isn’t. I’ve spent probably 15 months on Zoloft and I’ve also never been able to focus on the medicine. It’s just so much serotonin that I cannot make it work even with as small as 25 mg. Anyone else experience lots of frustration from let-downs with their meds?

    • #81420

      What ADHD meds are you taking?

      • #81594

        Sorry for the delayed response on my end. Dexedrine tabletes (Dexedrine in generic form) 10-40 mg a day as needed. SSRI Generic Zoloft (Sertraline) 100 mg a day right now. 100 mg of Zoloft has actually helped my anxiety with many things, but unfortunately focus is not the best with the medicine so I divide it up into 25’s or 50’s usually and swing it in multiple doses even though that’s annoying. If I don’t take Zoloft before approximately 3-4 P.M., I start to have a harder time getting to sleep, but ironically perhaps I notice that more at the higher doses. 100 mg seems kind of nice in the “moderate” dosing of Zoloft (Sertraline), so I like it at 100 mg but not higher nor lower.

      • #81765

        dex tabs 10-40 mg

    • #81437
      Penny Williams

      This wasn’t the right combination of medications for you. There are lots of others to try.

      There are two types of stimulants: amphetamine (Adderall, Vyvanse, Evekeo…) and methylphenidate (Ritalin, Concerta, Quillivant…). Almost everyone does well on one type or the other, but not both. It could very well be that you need to try a stimulant from the other category.

      A Patient’s Primer on the Stimulant Medications Used to Treat ADHD

      And if SSRI’s make you sort of lethargic, there are other medications to try for anxiety. Buspar is purely an anxiety medication and not an SSRI. It has a lower side effect profile than the anti-drepressants.

      Don’t give up just because a couple medications weren’t helpful to you. There’s a lot of trial and error involved in treating ADHD, anxiety, depression, etc… successfully.

      ADDitude Community Moderator, Author & Trainer on Parenting ADHD, Mom to teen w/ ADHD, LDs, and autism

      • #81595

        I’ve tried 30 medicines. I’ve tried every SSRI there is available in the United States. I’ve also tried Buspar before and found it to be less sedating, so that’s a great suggestion on your part. However, I already am splitting up multiple Zoloft doses in the day and Dextroamphetamine tablets, so I’d probably ditch the Zoloft if I did that, but I don’t see that happening. I don’t mind taking multiple doses of several things throughout the day though, as I’m to the point where I am willing to do whatever works and whatever needs to be done.

        ADHD Meds I’ve tried:

        Adderall tablets 10-20 mg, Ritalin 10-30 mg, Concerta 36 mg, Straterra (up to 60 mg), Wellbutrin (to augment Dexedrine; up to 225 mg), Vyvanse capsules (30-70 mg; tried all but the 40 mg capsule). Never tried Adderall XR, Dexedrine Spansules, Mydayis, Adzenys, Focalin, Quivallant (however you spell it). No interest in trying Mydayis at all at this time, but some interest in trying Mydayis later, however I’d really be more apt to trying Adzenys or Concerta again, and maybe Ritalin. I’m not sure which all was of much help, but probably Vyvanse the most and Dexedrine. Adderall tablets I felt super nervous on them, but it was my first amphetamine and I took it with Viibryd 20 mg or 40 mg I think, so I don’t have any idea how it would work if I took adderall tablets with Zoloft.

        SNRI: Effexor XR 300 mg, Pristiq 50-100 mg

      • #81764

        yeah tried ’em all

    • #81739

      Have you tried any other SSRIs?

    • #82761

      Hello, I used to call myself, The Poster Child for Anti-depressants… I quit taking any years ago because of the adverse and nasty side effects. However, over the year I would still experience depressive episodes and anxiety issues. I got worse up to and including most recently, extreme depression and raging. I finally saw a naturopath 2 years ago and determined:

      A few things to consider if you haven’t already (I had both):

      Possible Head Trauma – a good resource is the following book:

      Concurring Concussion – Healing TBI Symptoms with Neurofeedback and Without Drugs

      This is a wonderful (and easy to comprehend) book that describes “Traumatic Brain Injury (TBI). The information provided on injuries in history, from Henry VIII to Elvis Presley, I found very, very interesting!

      Synopsis: “…This lively, well-researched, and hopeful book is an excellent primer for anyone dealing with TBI and its aftermath, from victims to caretakers. It is clearly written and illustrated for the average reader, but contains information that may be new to many healthcare professionals puzzled by odd and unresponsive symptoms and the realization that time alone does not heal the brain. Conquering Concussion by Mary Lee Esty, Ph.D., and C. M. Shifflett presents history, new research, treatments, and 20 years of clinical case histories. These are real stories about real people struggling with post-concussion symptoms: terrible fatigue, headache and body pain, emotional swings, mental fog, insomnia, weight gain and balance problems. It shows how TBI symptoms overlap with other diagnoses such as ADHD and depression, and reveals the link with PTSD head trauma…”

      Transcranial Magnetic Stimulation (TMS)

      For Information purposes:


      I utilized Neuroasis here in Tucson for my TMS treatments. They provide a free 90-minute consolation with their onsite psychiatrist.


      OR…. You may have a (and I have this):

      Methyl-B Gene Mutation (MTHFR)
      My go to resource online is Dr. Ben Lynch at MTHR.net
      In layman’s terms, those of us with a MTHFR gene mutation have a highly reduced ability to convert folic acid or even folate into a usable form. Research estimates that as much as half of the population may have an MTHFR gene mutation. I don’t “methylate” (or I can easily over methylate) with B vitamins. I have to be very careful to avoid foods with synthetic folate or folic acid in my diet. (I found that if I eat anything with 20% or more folic acid [per serving] this is when I will experience rages and can go into days of depression). Several symptoms resulting from the mutation mirror other medical and mental issues such as ADD, ADHD, OCD, anxiety, depression, autism, etc. A great resource I found online is Dr. Ben Lynch who states: “…I believe the MTHFR gene mutation is a highly significant public health problem that is completely ignored. Yet, millions are suffering from pulmonary embolisms, addictions, fibromyalgia, miscarriages, schizophrenia, severe depression, cancer and autism to name a few…:

      You have some reading to do….but sooooo worth it. I am doing so much better now and no drugs. Working thru past bad habits I developed over the years due to my undiagnosed issues by going thru intensive outpatient counseling as well.

      Best of luck to you.

      • #83121

        I’ve heard of the methylation thing. Also, I have wanted to be off medicines for years but the no time off with classes has been very hard to manage withdrawal. I’ve attempted 16 times to come off Zoloft, and I keep failing because I have to come off dextroamphetamine in the process or it just feeds into the distress of the zoloft withdrawal. It’s awful, but I actually have to come off certain things in a certain way otherwise I get weeks of withdrawal and issues. Even if I wanted to be off medicines (which I do), I have to find an appropriate time frame where I can do so as some loss of functioning temporarily is inevitable with me. Also, I have a pituitary adenoma and a messed up HPA Axis, hypertension, sleep apnea, primary hypogonadism, secondary hypogonadism, and some thyroid issues as well as E2 and cortisol imbalances sometimes with elevated prolactin. This is my life… 🙁

    • #82793

      Hello! My 10 year old has severe ADHD. He takes 30 mlg of Adderall extended release. He takes this at 7 a.m. At 4 p.m. he takes a “booster” dose of 5mlg Focalin. Then at night to go to sleep he takes Clonidine. He is also on an iron supplement. I have noticed since being on the iron supplement it has made some of ADHD not so bad.Maybe It’s the type of medication you’re on we have tried SO many but by far this schedule of medication helps the most. Not sure if you have ever had the gene test done. But there is one that can pin point the best medications that”should” help you. My son’s came back a little inconclusive. We are looking into additional options such as counseling to help him figure out what works best for him and how he can manage is ADHD himself. I hope this helps.

      • #83122

        I’m glad to hear Adderall helps your son. I tried the tablets. Is your son on the capsules, if I may ask? I tried the tablets and I felt unbearably nervous and anxious/tremulous/etc.

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