March 14, 2019 at 8:56 am #110880
I have ADHD and have linked my symptoms to a drug that was given to my mother in utero. A synthetic progestin.
I urge you to check to see if your mother was given progestin in the 60s / 70s. There is a high chance this is the causal link to your ADHD in my opinion. There is a link with ADHD and ASD.
It is well documented that perturbations of sex steroids can adversely affect neurodevelopment in affected foetuses. (Gore AC, Martien KM, Gagnidze K, Pfaff, P. Implications of Prenatal Steroid Perturbations for Neurodevelopment, Behaviour, and Autism. Endocr Rev. 2014;35(6):961–991.) Many regions of the developing brain are sensitive to progestins, including neural circuits important for complex cognitive behaviors later in life. (Willing J, Wagner CK. Exposure to the Synthetic Progestin, 17α-Hydroxyprogesterone Caproate During Development Impairs Cognitive Flexibility in Adulthood. Endocrinology 2016;157(1)1:77–82.)
A recent study (Id.) documented adverse long-term consequences of 17-OHPC exposure during development on cognitive behavior of offspring. Administration of the drug to gestating rats led to dopaminergic innervation of specific lamina of prelimbic mPFC in juveniles, consistent with the possibility of impaired synaptic pruning. Additionally, 17-OHPC exposure impaired cognitive flexibility in adulthood—neurocognitive effects reminiscent of those often associated with developmental disorders such as attention-deficit hyperactivity disorder and autism. (Id.) The-treated rats were slower to make a cognitive switch to a new rule and continued to perseverate on the old rule longer than controls. (Id.) Abnormal levels of progesterone receptor activity and/or progesterone receptor activity at improper times during this critical period of connectivity may significantly alter the development of important behavioral neural circuits. (Id.) (see full link below – Christine wagner)
Other key relevant articles:
Autism link to higher levels of hormones:
Christine Wagner’s work
Evidence of strong association between asd and progestins
In France – same symptoms as me
Ellen c Grant:
Also there is an ongoing question of the effect of progestins on sexuality:
and warning signs of hormones were flagged up early in 1977 to this effect
In aquatic life there is a known link too
anecdotally autism is hypothesised as the “extreme male brain”.
March 14, 2019 at 1:49 pm #111700
ADHD has also been reported in grandchildren of DES-exposed women. Diethylstilbestrol (DES) is a synthetic estrogen banned following hearings held by Sen. Ted Kennedy in the early 1970s. DES was prescribed to pregnant women from 1940-1971. Caused cancer in some children of the women. Now found to cause ADHD in the grandchildren:
Association of Exposure to Diethylstilbestrol During Pregnancy With Multigenerational Neurodevelopmental Deficits
Marianthi-Anna Kioumourtzoglou, ScD1; Brent A. Coull, PhD2,3; Éilis J. O’Reilly, ScD4,5; et alAlberto Ascherio, MD, DrPH5,6,7; Marc G. Weisskopf, PhD, ScD3,6
JAMA Pediatr. Published online May 21, 2018. doi:10.1001/jamapediatrics.2018.0727
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