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@allishad002. I’m also treatment resistant and have tried more than 20 meds. I ended up in the hospital 2 twice while they tried ECT. It helped a little I’m not suicidal now but still suffer from major depression and anxiety and ADD. SSRIs didn’t work unless I took something like Rexalti which really helped but then I got akathisa. I’m on an MAOI now and Klonopin plus a small dose of seroquel for sleep. I still feel like it’s been forever since I have felt good. I cancel plans often, hate talking on the phone, and cancelled all but one holiday dinner at my house this year . I feel like I’m a waste of space and I’m honestly just waiting to receive divorce papers; why shouldn’t my husband be with someone fun and happy like I used to be…he deserves to be happy.