As a migraine sufferer myself, I know the pain of those is unbearable. Since I don’t have ADHD, I can’t comment on how to specifically combat the drug combination trigger. However, there are some triggers we just can’t steer clear from. You might speak to the Neurologist or a doctor well versed in migraine about migraine preventatives if you feel Vyvance is really the only ADHD medication that really works. Preventatives come with their own set of pros and cons, like any drug – but they are an option to stop the migraine before it starts.