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Yes! MTHFR genetic polymorphisms can cause depression, anxiety, and a long list of other things. It is common in those with ADHD and/or autism. My son has the genetic abnormalities and has both ADHD and autism. Here’s more on MTHFR:
ADDitude Community Moderator, Author & Mentor on Parenting ADHD, Mom to teen w/ ADHD, LDs, and autism