I take Concerta 37 mg, 3 times a day. I do not take weekends off. My psychiatrist doesn’t recommend weekends off as my ADHD doesn’t take weekends off. I seem to be doing well on it, I’ve been on it for a few years. It’s very common for those of us with ADHD to suffer with depression and anxiety so I can’t attest to it being the medication wearing off, but I’m not a doctor.
Those feelings aren’t fun, I live with these challenges too.