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A year ago, Adderall XR became less and less effective for me. My doctor switched me to Vyvance for a month but I only made it about ten days before discontinuing. Unlike Adderall, which had no side effects, Vyvance use included aggressive thoughts and irritability. I always knew when it was wearing off because I invariably developed a severe headache. To top it all off, it only seemed active for two to three hours, no better than the Adderall.