Hi! My son has been on Intuniv for a number of years now and the samething happens to him.. His Pediatrician instructed us to give it to him in the afternoon to prevent tiredness. He said about 6 hours prior to bed(which for him is 1pm). Most times the effects of tiredness start taking effect then. But, it won’t matter because he’s in bed or sleeping. I’d try that. 🙂