My son has been taking them for about 2yrs now. He has never been able to fully come off of his ADHD meds while on them and I do believe they no longer work as well as they first did so we might take a break from them this summer. They are large pills and have a horrible smell so it took awhile for him to be able to take them without gagging every single day. I do think they are worth trying and I haven’t found anything comparable ingredient wise.