Reply To: Built up tolerance to 20mg XR — how long a break to restore effectiveness?

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The question of tolerance is something you should be discussing with your psychiatrist to be honest. That being said the afterlife of Adderall is 9-14 hours meaning that after maximum 14 hours there is none of the medication in your system to effect you in any way. Adderall is not even detectable in the blood stream after 3 days of not taking it.
I would like you to specify these effects you are talking about being “less noticeable”? The idea of Adderall ,correctly dosed, would be that you would not “feel” anything. You would just start feeling like your focus is not there and you are easily distracted again or daydreaming when you should be studying for an exam or reading a report you must understand and just can’t muster the motivation to do it. Those are the things that disappear from your life and you will know your dose has become ineffective. Adults generally start showing tolerance issues much sooner than 10 years and even 3 years. I also know that amphetamines is one of those medications that rarely become completely ineffective for people even when they have developed a tolerance. I had to have my Adderall adjusted after the first 2 years from 10mg tablets 2 times daily to 10mg tablets 3 times daily. That solved me for 2 more years then we went to 20mg tablets 2 times daily for 2 more years and then to 30mg in the A.M and 20mg at noon. This is all IR formulation and then after 3 more years I was put on 30mg Adderall twice a day….that was fine for about 2 years and now I jut recently switched it to 20mg IR Adderall 3 times a day. The psychiatrist says that if this is not the solution we will start 20mg Adderall XR in the A.M. and then 20mg IR Adderall in the afternoon to get me through the rest of the day.

I think you just need the psychiatrist to give you a 10mg IR or 20mg IR in the afternoon or early evening to hold you through until bedtime. The thing is 30mg Adderall XR may also do it as you’re saying effectiveness not duration of effect. There is a big difference and can sometimes be overlapping issues.Are you sure to not take it with Acidic Drinks like Soda Pop or Orange juice? Do you take Omega Oils daily to replenish your amino acids which help your body produce dopamine? Even try the L-tyrosine supplements which help most people with the meds not being ” as effective” as they used to be.

Your question about “resetting tolerance” is usually only applicable with people who have been on extremely high dosages like 60mg per day…or more. 20mg XR daily even 7 days per week are not going create long term interruption from all I have researched on the subject.

  • This reply was modified 1 year, 8 months ago by Javid1980. Reason: spelling