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In regards to your post. This was me!! The Adderall ER 20mg worked like night and day, however I felt so lethargic, and like I was riding a roller coaster all day. I was to the point I did not want to take it because of how it drained me. I spoke with my doctor, and requested that I be given a different medicine. He allowed me to stop the XR and take the 20 IR. THIS WORKED!! No dramatic symptoms, fatigue, or feeling like you want to give up on the medicine. The XR just does not work for some. Remember we are wired differently than everyone else. If you have a great understanding doctor who understands Adult ADHD, he will let you guide your therapy. You know how the medicine works for you. Good luck, and experiment with different doses, and brands.