Reply To: Methylphenidate ER Side effects normal or not?

Home Welcome to the ADDitude Forums For Adults Treating Your ADHD Methylphenidate ER Side effects normal or not? Reply To: Methylphenidate ER Side effects normal or not?


I would NOT ACCEPT those side effects from treatment. Although they are brief now, they may disappear or intensify based on situation and if you cant predict that, it is not a good thing. The post above is right that you should start low and gradually increase the dose over the period of several months. You will need at least 2 weeks on a dose to really know how it will affect you.
I am not your doctor and do not know your case so it would be difficult to determine the urgency or overall impact of your side effects. Sometimes you can push through the side effects and sometimes you really have to drop the dose back or change the medication. That is between you and your doctor. I can tell you that dose adjustments over the course of 3 weeks is not appropriate. Work with a psychiatrist if you can and work through your dosing slowly.

I work in pharmaceuticals and figuring out dosing for new drugs is one of my areas of focus. In my case, I worked through methylphenidate, strattera, and adderall. Methylphenidate, even at lower doses, really made me feel sad and depressed for no good reason. It was terrible Stattera did nothing for me at all. I worked my dose of adderall up from 5 mg up to 20 mg in 5 mg increments and then went to adderall XR 40 mg (equivalent to 20 mg twice a day). I noticed that the dose worked well but I also knew that sometimes taking 20 mg in the AM and 10 or 15 mg in the PM worked better than 20 mg twice a day (using XR does not allow this flexibility). Now I take a split dose Adderall XR, two 20 mg capsules, one capsule before breakfast and one after breakfast and at least 45 min later. This allows a smoother increase of drug into your system and alleviated the jolt I occasionally got shortly after taking two 20 mg XRs together. This strategy can also increase the effect duration through the day a little bit. Even though drug dosing is an area of expertise of mine, I worked closely with my psychiatrist over several months to get the right drug and right dose correct. We learned a lot from each other through the process and it was worth it. There was a lot of pill cutting and a lot of patience on my part (dont go straight to an extended release for convenience until you are very comfortable with your dose!!!). Your efforts will be rewarded.
Lastly, give your body a break from the medication on any day you don’t need it or on days when you have heightened anxiety. If you ultimately go to an extended release form, keep some immediate release doses in your medicine box for days when you don’t require prolonged focus or to take a bump up around 3-4 PM for those really long days. Please keep in mind that the stimulants are appetite suppressants, don’t forget to eat well and lay off simple sugar and corn syrup. Usually on weekends when I am off stimulants, I get the urge to binge eat unless I forced myself to eat well during the week, even when not hungry.

I hope this helps. Remember, we are all different and will respond to these drugs in our own way. ADHD is a gift and a super power, You may not think that now, but we are very unique and when we harness that gift, we offer the world great things.

  • This reply was modified 2 years, 1 month ago by Outsider.