I’m having the same issue with Vyvanse (for adult ADHD). Started at 10mg and now up to 60mg. Each time I added 10mg (starting with the first dose), I noticed that my head seemed clearer, like it was easier to think, prioritize, and I was less irritable. It even improved my long-time depression. However, this effect wears off after about 3 days, give or take, every time I increase the dose. Having read some other related pages along with this thread, maybe I’ll ask about Concerta and if that doesn’t work, look into the MTHFR mutation, since it seems relevant to my mental health conditions anyway.