Managing Medications

8 ADHD Medication Fallacies That Persist: Optimal Adderall Dosage, Risks and Interactions, Side Effects & More

Optimal dosage is pegged to weight. Afternoon stimulants disrupt sleep. Adderall causes high blood pressure. And other falsehoods about ADHD medication that may put your treatment plan at risk.

Adderall dosage: Doctor holding pill bottle up to face with ADHD medication inside it
Doctor holding pill bottle up to face with ADHD medication inside it

Adderall dosing – and all ADHD medication dosing, for that matter – is opaque and variable. Is there an optimal Adderall dosage for adults? Should your stimulant dosage change over time? What are the signs of an ineffective dose? With so many questions and misconceptions – even within the medical community – it’s critical for patients to research dosing for Adderall and other ADHD medications before using them to treat attention deficit hyperactivity disorder (ADHD or ADD).

Take Janet, a 37-year-old marketing manager, and her first experience with Adderall – “I was glued to the sofa, unable to move for two days,” she said. “I looked and felt like a zombie. It scared me off ADHD medication.”

Janet later learned, after attending a local adult ADHD support group, that it takes weeks for most people to tolerate the Adderall dosage her doctor had prescribed — and that many people were taking half that amount. “I should have educated myself first, instead of trusting the physician,” Janet says.

Janet’s experience is becoming less common, though adults with ADHD do still encounter professionals with questionable prescription practices. The bottom line? Be a smart health-care consumer, and take note of these red flag statements (and medically reviewed rebuttals) surrounding Adderall and other popular ADHD medications.

1. “My adult ADHD patients do best on Adderall (or this other stimulant medication).”

Adderall is among the most commonly prescribed ADHD medications. It’s also a stimulant – considered first-line treatment for ADHD. But these factors don’t mean that physicians can “play favorites” with it or with stimulants as a class. Those who do don’t have an empirical basis for doing so and are gambling with your chances of success.

[Read: A Patient’s Primer on the Stimulant Medications Used to Treat ADHD]

Simply put, there is no way to predict how a patient will respond to Adderall or any stimulant, whether a methylphenidate (MPH) or amphetamine (AMP), until they try it.

Physician and ADHD specialist Patricia Quinn, M.D., suggests trying both classes of stimulants (MPH and AMP) before deciding that stimulants won’t work for you and moving on to a nonstimulant medication or another ADHD treatment: “You might even try several meds within the same class before switching to another stimulant class,” she said. For example, Ritalin LA and Concerta are both long-acting methylphenidates. Due to their different delivery mechanisms, however, each brings different results — and potential side effects.

2. “This is an average dose for adults with ADHD.”

Just as a professional cannot predict which medication will work best, they also cannot predict an optimal dosage – there is no “average” or optimal dosage of Adderall — or any other ADHD medication.

The ideal dosage of Adderall or another ADHD medications is identified using a method called titration: carefully increasing the dosage over time, until noticeable benefits are achieved and side effects are kept to a minimum. The approach should always be “Start Low, Titrate Slow.” In general, stimulant medications should be administered at the dosage that is both lowest (to keep side effects at bay and avoid overdosing) and most effective to the individual patient, and should also be adjusted according to changing needs.1

Adderall is available in several formulations and doses. Immediate-release tablets can be taken several times a day, or during specific activities, depending on patient need. Adderall XR is a one-daily, timed-release stimulant. How a patient responds to a prescribed dose depends on many factors, including:

  • Your history of taking stimulant medications. Those who have taken stimulants in the past might be less response-sensitive than people who have not.
  • Genetic differences — some people metabolize the medication more quickly than others.
  • Co-existing conditions — anxiety or a mood disorder, for example, and their current treatments.

3. “For an adult of your height and weight, we start with this dosage.”

ADHD medication dosing is not related to an adult’s height or weight. The Adderall dosage of another adult your age, weight, and/or height is irrelevant. Clinicians, however, typically start adults at a low dose (usually 5 mg), and then adjust as needed.

4.“You can’t take Adderall if you have hypertension.”

Adderall is linked to increased blood pressure and heart rate,1 so adults with ADHD should have a thorough physical, including screening for heart problems, before starting Adderall or any new medication.

Hypertension alone does not preclude a patient from taking ADHD medication: “I would say that it is never a contraindication,” says Margaret Weiss, M.D., Ph.D., an ADHD clinician based in Vancouver, British Columbia. “You treat the hypertension first. And, in fact, there are medications for ADHD that lower blood pressure.” These include generic guanfacine and its longer-acting brand-name formulation, Intuniv, which can lower both systolic and diastolic blood pressure. These medications are often used as an alternative to, or in conjunction with, stimulants.

5.“Sure, continue consuming caffeine, if you like.”

Many adults with ADHD rely heavily on coffee or caffeinated sodas. Yet caffeine may exacerbate the effect of Adderall and other stimulant medications, creating anxiety and heart palpitations. “Some people can tolerate stimulants and still have some caffeine,” Weiss says. “For others, caffeine interferes by creating or exacerbating side effects, making it impossible to increase the stimulant to therapeutic doses.”

You may not be able to determine what’s causing these side effects — the stimulant or the caffeine — unless you gradually wean yourself off caffeine before starting stimulants. (Try to break the habit in advance, though, to avoid mistaking a headache due to caffeine deprivation for a medication side effect.)

6. “You should see a huge improvement in ADHD symptoms right away.”

The potential positive effects of Adderall, other stimulants, or medical treatment for ADHD shouldn’t be oversold. Knowing that stimulants are first-line psychopharmacological treatments for ADHD doesn’t mean we can predict how any medication or dosage will affect a particular individual. “It’s true that some symptoms may improve dramatically in days, or even in hours,” Weiss says. “But it is important to wait to judge the full effect of the medication, because it can take some time for all the data to accrue.”

Judging a medication’s effectiveness requires more than a physician asking, “How are you doing?” It requires at least two steps:

  • Taking careful inventory of the challenges you face (writing them down, one by one), before you started medication
  • Regularly reviewing each challenge as treatment progresses, in order to track improvement (or not), worsening symptoms, or new side effects.

During this titration phase, experts recommend talking with your physician weekly and using an ADHD medication tracking log like this. In-office visits should take place every three to four weeks to review side effects, physical health, patient and family well-being, and other therapies when indicated.

Many experts and patients report that too few physicians closely monitor medications used in adults. “It’s critically important to do, but the utter paucity of clinicians doing it is shocking,” says Stephen Hinshaw, Ph.D., an ADHD researcher and professor of psychology at the University of California, Berkeley. “You can’t notice small improvements or side effects without a monitoring sheet.”

Weiss recommends using rating scales that measure a broad range of symptoms and functioning; in other words, a metric for tracking how you’re doing in life. The Weiss Functional Impairment rating scale is a good place to start. Having a tangible method for observing change makes the target concrete and keeps it in focus.

As you face challenging situations in your life, you can gauge how your responses differ from those in the past. “It can also take time to notice the differences in how people are reacting to you, or to evaluate changes in how efficient or how much better you’ve become at your job,” Weiss says.

Weiss offers these guidelines:

  • Symptoms tend to improve within hours after taking stimulant medications, but it can take a few days to fully appreciate these changes.
  • Nonstimulants take approximately five days to go into effect after dosage changes, and it often takes six to eight weeks to realize the full benefits of medications like atomoxetine.
  • Functioning improves within months.
  • Developmental changes happen over years. For example, the individual who never had a friend can now make and keep them. An adult who could not keep a job can now hold onto one for a year.

7. “If the stimulant disrupts your sleep, we will have to switch you to a nonstimulant.”

The causes of sleep problems among adults with ADHD are multi-faceted, and may not be fully understood by the treating physician. Increasingly, research on the ADHD brain is pointing to neurophysiological differences in circadian rhythm, the inner biological clock that tells us when to go to sleep. But there are other ADHD-related obstacles to sleep, such as being unable to “put the brakes on” a busy brain.

In evaluating the adverse effects of any ADHD medication on sleep, it’s important to pay attention to timing. Perhaps sleep problems are caused by the rebound from the medication’s wearing off. In that case, you should try taking the medication earlier in the day or taking a nap midday while the full dose is in effect. A no-risk trial nap can help to demonstrate that the medication is not causing the sleep disturbance, but rather the ADHD itself, and lack of medication in the rebound period. Some people with ADHD sleep better on a stimulant; such medications stop “brain noise” and increase focus on going to sleep and staying asleep.

8. “If you think that Adderall (or another stimulant) has stopped working, we should try something else.”

Before ruling out Adderall or any other ADHD stimulant, consider that the medication may have stopped working for any of several neurobiological reasons. After that, take a step back and try to remember what life was like before you started taking the stimulant. Is it better? Worse?

Adults who are diagnosed with ADHD later in life typically develop the habit of paying attention only to the exciting or new. After a few weeks of experiencing the “novelty” of improved symptoms, it’s easy to forget how far you’ve come. This is another reason for keeping written records of baseline symptoms and of the progress you’ve made. It’s the only way to know if the med is doing its job.

[Download This Next: The Ultimate Guide to ADHD Medication]

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View Article Sources

1 Federal Drug Administration. “Adderall Medication Guide.”

9 Comments & Reviews

  1. Some of this needs to be taken with a grain of salt. My doctor made some similar comments that I took as encouragement. It is so difficult to find a doctor to help with ADHD. It took me 3 months to find and get an appointment with a Psychologist. I am very grateful Strattera works for me. Not so much with my hyperactivity, but with my racing thoughts. With those under control life is much more enjoyable.

  2. I don’t think I understand the sentiment of this article….to not trust the professionals who went to school for a decade to understand the condition as well as the medication for treatment? I think this is subjective, and based on just one person’s bad experience. Which is unfortunate, but I’ve been having a great experience so far with my physicians as we explore the best treatment for my attention deficit symptoms. With doctors and ADHD patients in my own family, I can surely say everyone is different and will respond differently to treatments. It’s really a trial/error type of process.

  3. This article is spot on, at least for me.

    I live in Canada (where you can’t see a psychatrist without a referral). My family doctor did refer me to a psychiatrist for diagnosis when I said I think I have add however, the psychiatrist left it up to the family doctor to prescribe and monitor medication.

    This family doctor doesn’t log anything, just quickly askes how I’m feeling sometimes. Then when I said I think my 18mg concerta dose is not enough and want to try 27, his attitude was if 18 isn’t enough then we need to big or go home and put me up to 36 which seemed too much. After not finding a concerta dose that works, (finally tried 27mg). I might ask to try ritalin or adderall. I just hope he can prescribe those properly.

    The bottom line is, Just because you may have a competent doctor in prescribing ADD meds, doesn’t mean everyone else does.

  4. An excellent article.

    My only quibble is that it might have been prefaced with a sympathetic nod to the bulk of specialists doing their level best to help people, albeit imperfectly. That said, too many clinicians succumb to a swag of cognitive biases and assorted other very human flaws that can make for some pretty crappy judgement. Most are too damn busy and don’t have the time to keep up to date with the latest research. Sadly, some don’t care enough to make the time, or deal with the things that skew their judgement, or just don’t have a knack for the fuzzy, human side of medicine. Nobody’s perfect.

    A little while ago, I worked for a national college of physicians on a programme to promote what’s sometimes called ‘right care’, i.e. avoiding the over-use of medical advice, treatment, and procedures for which there is little good evidence of cost-effective benefit and/or a real risk of harm, and the under-use of the best, evidence-based medicine. (There’s now a stack of research on this and what drives clinicians to make bad or ‘low-value’ calls, e.g.,, etc.) Together, these clinical behaviours mount up to big costs worldwide—costs to our personal health, wellbeing and bank balance, not to mention an enormous and unnecessary toll on the public purse. Here in Australia, an estimated 20–30% of patients receive care that is unnecessary, ineffective or potentially harmful. And, according to Boston Consulting Group, government and the private sector spend around A$30 billion each year on low-value care. Even in the US, which boasts the world’s best medical care (highly debatable!), doctors are still making basic medical mistakes. For instance, up to 90% of antibiotic prescriptions are for mostly viral upper respiratory tract infections. (Happy to supply references if people are keen to dig deeper.)

    How do we turn this around? First, we (doctors and patients) need to admit we have a shared problem. And it turns out one of the most effective ways to start dealing with it is to empower patients with solid, understandable, evidence-based advice. Something ADDitude magazine does in spades. Good job, folks!

    But I digress…

    I recently got my formal ADHD diagnosis. (Yay me! :-/ ) I had already done a lot of my homework, for which this site proved immensely useful (thanks again!). I’ve an excellent relationship with my GP, who, at my request, packed me off to a psychiatrist who knows a thing or two about adult ADHD. I found the her to be a lovely person, very professional, and with none of the god syndrome one too often sees in medical specialists. A warm, no-nonsense professional who, I’m happy to say, treated me like an adult and appeared to listen to my concerns and questions. So, 10/10 for bedside manner.

    But… As lovely as my psychiatrist is, she is also human. And one or two things about our first appointment still irk me, and a couple of them are on this list. One that isn’t: she remarked that I could use the medications (Dexamphetamine and Clonidine) ‘as needed’. This is something that very much appeals to me; the last thing I want is to become overly dependent or outright addicted. I had tried Ritalin before and really didn’t like the side effects, including the kind of see-sawing of emotions and energy.

    Well, silly me. Of course a stimulant medication like Dexedrine isn’t something one can take or not take like a headache tablet. I’m partly to blame, of course. I know enough to have pulled her up on this; I just didn’t have my wits about me. Nerves, I guess. It’s not every day one gets diagnosed with a neurodevelopmental disorder that explains an awful lot about why one’s life is so screwed up. Still, she could have been clearer about the meds and I’ll gently raise it next time. I do feel she’s someone I can work with and it’s hardly a hanging offence, but it is important. And it’s important that she knows I’m a partner in this, not just a patient.

    So, perhaps a good follow-up article to this one (or add a link, if it already exists) might be some tips on how to talk to/work with your clinician(s). You know? How to deal with difficult shrinks, the sorts of questions to ask, when and how to query their judgement respectfully (but firmly), how to establish a good working relationship, how to deal with the trial-and-error drag of finding the right clinician… That sort of thing.

  5. I finally found a great Dr. a 7 years ago. We had weekly appointments and we increased my dose gradually. Not on a scheduled “two week” or “monthly” basis. I finally found my right dose. He let me decide when the dose felt ok. I’m on a fairly high dose of Adderral but it works for me. I ended up moving out-of-state to Florida and finding a Dr. here was a nightmare. it is wasn’t “this is what the recommended dose is for your height and weight” it was “hmm, why don’t we try something else”. one Dr. prescribed a very low dose of Vyvanse and I was a mess. The Dr. I found now only does medication management… it sucks and I always feel like I have to say “Everything is GREAT” so he doesn’t change my dose.

    Florida is extremely strict with controlled medications, I get it, some people abuse them. Doctors are afraid to prescribe anything outside of the recommended dose. What happened to doing what is best for your patients? After being diagnosed and on the right dose of Adderral, I was able to slowly get off of anxiety meds and a mood stabilizer. I consider that a win.

  6. I agree with a lot that was stated in this article. You also need to research for yourself because most GPs really don’t have the time to keep up to date on ADHD; many will gladly accept any research you have to share.
    We started out with our kids being diagnosed and treated by a pediatrician who only saw them monthly for med checks, so it was a very slow process to find the right meds and as they aged we had to change type and dosages. We were so grateful for the nurse practitioners that he had as they knew more than he did about ADHD meds and their side effects and even drug interactions (who knew that taking Ritalin and steroids could lead to paranoia; happened to my adult ADHD person when he hurt his back).
    The main problem in our household is that two of the three ADHD persons need a dose that is higher than what the government allows to be prescribed by a GP. The adult has seen a psychiatrist for this and it has been an absolute nightmare with the insurance company as they do not want to pay for the dose needed despite it being generic. They have even questioned the credentials of the psychiatrist who has been in practice for 40 years and the needed dose even though he has been on it for 32 years. The adolescent found a workaround in drinking caffeine in the am with their XR so that they don’t have to wait for the hour it takes for the XR to start working. Once again, the insurance company doesn’t want to pay for it despite it being a generic and is max dose allowed for a GP to prescribe. It is so frustrating that in the USA we have a dose limit on drugs that are prescribed by effectiveness and not weight and age.

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