The ADHD Brain

Is ADHD a Spectrum Disorder?

New research suggests that ADHD comprises several meaningful subgroups — each one tied to a weak connection in the brain’s neural networks. Mapping the regions of the brain that control attention, impulsivity, and emotion, can help explain why scientists are studying the “white matter” connections between these circuits.

According to the Diagnostic and Statistical Manual of Mental Disorders (DSM-V), ADHD comprises two predominant sub-types: inattentive and hyperactive/impulsive. However, researchers studying the neuroscience of ADHD believe the condition is far more nuanced.

Some children with ADHD are anxious. Some are angry. Some don’t have problems with emotions, but can’t pay attention. Attention deficit hyperactivity disorder (ADHD or ADD) is variable. Children with ADHD appear to exhibit different profiles of emotional regulation and attention problems, perhaps associated with different patterns of maturation of brain networks. The ADHD brain is quite different.

The Biology of the ADHD Brain

Brain networks, of course, are numerous and complicated. At a cellular level, neurons transmit messages and make connections between and within different brain regions — the frontal lobe, the temporal lobe, the parietal lobe, and the occipital lobe — as well as subcortical structures. Brain scans show us that ADHD brains are, on average, about 10% smaller than neurotypical brains. Other scans show that connections in the brain networks are underdeveloped, suggesting problems with the quality of the connections between neurons, which are called axons.

As a child matures, the white matter – or myelin sheath – around the axons continues to develop and mature into early adulthood. For people with ADHD, the brain could continue to mature until they reach their 30s. This growth in myelin is like replacing a dial-up telephone Internet connection with a fiber optic cable. It makes neural transmissions faster and more efficient.

Recent research has shown that there are changes to axon growth in the ADHD brain as well. Neuropsychological studies suggest that people with the condition process information more slowly, and there is more ‘noise’ during their processing. This may be related to immaturity of myelin fibers, which makes the axon’s neural transmission between certain brain circuits less efficient.

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My newest research has concentrated specifically on the connections between and within the frontal cortex, the parietal cortex, the basal ganglia, the thalamus, and the nucleus accumbens. Underdeveloped axonal fibers in the connections between these regions may help to explain the inattention, impulsivity, and emotional regulation problems so common in people with ADHD.

The fronto-cerebellar network links the frontal cortex to the cerebellum. The executive function network links the frontal cortex, the parietal cortex, and the subcortical areas (basal ganglia). The attentional network links the frontal cortex to the supplementary motor cortex and the parietal cortex. Each network could be a locus of dysfunction for people with ADHD.

Two fundamental kinds of brain signaling must be considered to understand ADHD.

Bottom-Up Signaling: The signaling from the back of the brain to the front of the brain, and from the interior of the brain to the outer part of the brain is bottom-up signaling. Those signals respond to sensory input — what you see and hear — and immediately trigger attentional capture or emotional reaction.

Top-Down Signaling: In response to these bottom-up signals, top-down signals come from neurons projecting either from the prefrontal cortex backward towards the back of the cortex or downward into the interior of the brain to modulate the spontaneous bottom-up signals. The top-down modulatory signals are based on your goals, your learning, or what you want to be doing. They respond to internal signals instead of external signals.

[Click to Read: Uncomfortable Truths About the ADHD Nervous System]

In a neurotypical brain there is a good balance of bottom-up and top-down signaling. Bottom-up systems appropriately interrupt attention when something important happens (e.g., someone physically draws near, a loud sound, or if you are a child – the teacher frowns). These are occurrences that your brain recognizes as something unexpected, not-supposed-to-happen in the moment, and makes you notice so you can modify your top-down response.

The ADHD Brain

In ADHD brains, however, these top-down signals are relatively weak. One hypothesis is that they are overpowered by the much more powerful bottom-up signals. And that imbalance manifests in several different ways, depending the area of the brain impacted. Three common manifestations of this imbalance are inattention, impulsivity, and emotional regulation.

Inattention in the ADHD Brain

The problem: A child with ADHD becomes so hyperfocused on a video game that it is not easy for him to stop playing. Or he can’t focus on his homework when siblings are watching TV or playing nearby.

The explanation: The “automatic attention capture system” in the brain is activated by the stimulation of the video game or the enticing distractions nearby. It sends a bottom-up signal to the parietal lobe, which should reply with a top-down signal reminding the brain of its long-term goals and obligations. In ADHD brains, the axonal fibers in this top-down reply are underdeveloped, so the message to ignore the environment and refocus on the goals is lost. There is not enough top-down control.

Studies that observe the brain using an fMRI scanner while children work on an attention task (like a math problem), show the frontal-parietal attention network functions poorly. Additionally, in research that examines the axon fibers connecting the attention circuits of the brain, it’s found that certain fibers are underdeveloped, which could explain the under-functioning of the front and back areas of the attention network. It’s as if they are not well-connected, so they are not talking to each other. Because the front of the brain can’t capture attention, the behavior is not suppressed.

Impulsivity in the ADHD Brain

The problem: A child with ADHD blurts out answers in class, says something hurtful to a friend without stopping to consider the consequences, or literally leaps without looking and ends up injured.

The explanation: The thalamus is the interior area of the brain that helps to signal the need for response inhibition; in other words, it helps stop you from performing a behavior that is not in your best interest. It operates like a gate, sending signals to allow and stop behaviors as is appropriate. In ADHD brains, the limbic-hippocampal connections relaying these warning signals from the thalamus to the frontal cortex are impaired. It’s as if the gate is broken, and behavior doesn’t get suppressed when it should.

People without ADHD have the ability to stop, mid-stream, if they recognize a person is not smiling or responding well to something they are saying.The average adult needs only 200 milliseconds of warning to interrupt something they are about to do, even if they started doing it. The average child needs about 280 milliseconds. The child with ADHD needs 20 to 30 milliseconds longer warning, which is an eternity when it comes to behavior control because behavior is so fluid.

Emotional Control in the ADHD Brain

The problem: A child with ADHD responds in overblown, extremely emotional ways to small setbacks or challenges that most children would shrug off. Perhaps she suffers from anxiety or worry due to school frustrations, or she throws temper tantrums that last hours  because she can’t regulate her anger. Long-term rewards are meaningless; immediate gratification is everything.

The explanation: The amygdala are two internal brain regions that are involved in emotional reactions and decision making. When flooded with anger or worry, these regions deploy bottom-up signals to the cerebral cortex. The insula, a region of the cerebral cortex, should then respond with top-down strategies and goals designed to inhibit an individual’s emotional response in line with the goal. This is what helps you take a deep breath and think before acting on a sudden emotion. In ADHD brains, this insula-amygdala connection is weak, which can lead to a breakdown in regulating negative emotions. Emotional regulation is a big part of ADHD that has been traditionally ignored.

At the same time, people with ADHD over-respond to rewards when they are immediate, and don’t remember or value future rewards, which indicates a potential breakdown in the regulatory system. When comparing ADHD brains to people without ADHD, we see that the connection between the prefrontal cortex and the reward system (which is partly in the nucleus accumbens) has reduced activation, especially in the dorsal part of the prefrontal cortex. This could explain overexcitement, frustration and anger, and inability to respond to delayed rewards.

ADHD Spectrum: Not all Children Are the Same

ADHD is not a breakdown of the brain in one spot. It’s a breakdown in the connectivity, the communication networks, and an immaturity in these networks. These brain networks are interrelated around emotion, attention, behavior, and arousal. People with ADHD have trouble with global self-regulation, not just regulation of attention, which is why there are attentional and emotional issues.

In the future, brain imaging may lead us to classify ADHD according to various valid sub-types like those explained above. Currently, though, brain types determined by brain scans are just speculation by physicians. Due to variability in brain-imaging equipment and analysis procedures it is not recommended to pursue a brain scan to help diagnose symptoms of ADHD in anyone. It may give the clinician a little more confidence in their ADHD diagnosis, but that may not be valid; it’s important to note there’s an improvement in accuracy from simply using a standardized rating scale too, and that’s a lot less expensive.

ADHD Spectrum: Next Steps

Joel Nigg, Ph.D., is a member of the ADDitude ADHD Medical Review Panel.

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12 Comments & Reviews

  1. Okay, sounds interesting, I’m not sure I agree 100% with the hypothetical parts. Here’s why, IQ is generally higher in people with ADHD which is the actual transmission speed of the neurological fibers. This cannot be changed, and although the sheathing helps the signal travel faster you mentioned the testing of certain fibers, which fibers are important.
    Here is a slightly tangent theory, what if the brain in someone with ADHD is fundamentally wired differently. So the DNA is structuring the fibers so that it is not establishing the same strong network connections because it is placing emphasis on direct pathway connections (serial) at the expense of parallel connections. This could be evolutionary adaptation for tasking purposes, such as the old hunter gatherer hypothesis. It would stand to make sense, inattention is more the hyper-sensitivity to distraction, but honestly noticing a leaf move at 200m is important when your hunting and a T-Rex could be near. I’d rather have that ADHD kid on point during a patrol because he is going to notice everything including smells, you can smell cigarette smoke over a mile away, not a bad trick, but wouldn’t 1.5 miles be better? Not to mention hearing etc…
    Impulsivity is an issue, or is it the side effect of hyper-reflexes, which is measurable and linked to attention. Try drag racing someone with ADHD, once they “lock in” on that light try and beat there foot to pedal instinct. Yes there are negative consequences but is that exacerbated by they world as it is today?
    Emotional control I would think is a little multi-faceted, one is the dopamine hit you get when you get what you want which would encourage risky behavior. Could be bad, or good if you think far back enough where our adventurous urges brought us out of caves and enabled us to use fire and hunt larger and larger beasts. The other is this, try having heightened hearing in a world that is so noisy, or heightened touch where you skin feels even the slightest breeze (which of course you notice), or eyes that see everything. Increased smell when everything smells different (and you notice) so much so that too much incense or strong smells can even make you sick. The world is an expansive place with all this extra stuff (noise) going on, so why wouldn’t you seek solace or get a little impatient. Could it be that feeling more sad or happy is a direct result of this cause and effect reward system?
    Maybe, just maybe, these differences are a purposeful adaptation that happens in a specific set of off-spring that increase the chances of exploration while the other set of off spring “hold the ground” with brain developed for more parallel thinking.
    Or maybe I’m just a very successful ADHDr/polymath that wants to believe this issue I have is something more than an aberration, much less a malformed brain. Maybe humans have developed in a way that allows a percentage of offspring to develop brains structured differently because of task organization, neither better or worse, just different for their different roles. Yes with maturity I’ve found that I do think more before I do things and yes the safety factor in adventurous activity has increased about 100%, but then again it was time to have kids so maybe there is a correlation with the myelin sheathing there as well. If we survived we reproduced and that worked out okay because I’m here.
    I think there should be more emphasis on why brains develop this way, what actual advantage each type of brain brought to the collective table. Not so much that a certain fiber developed slower, but why it would and is there a corresponding fiber that is perfectly fine and/or developing faster. Maybe reverse engineering what you find; not as if it were a problem but rather as if it were a solution to a problem.

    1. I am merely a lay person (adhd combined type plus comorbidity-dyspraxic..I am also dyscalculic)-diagnosed at 54 at my Uni and through my gp for these splds.I do find your extrapolation makes a good point-I am of average intelligence but some ways I have ideas etc makes others exclaim ! In a good way mostly ☺ I think your point can exist as an expansion from ‘their’ point- but yes,left as is can severely restrict the overall theme back to “retarded” status left with bare facts, when as you say intelligence is often higher or at least average;which is very important and can and should co-exist with the findings as another exploration that goes along with the physical evidence found. “So how do we explain the perceived or actual higher I.Q? ” -Would definitely be a route worth exploring. I think this is where it has similarities with ASD (superficially,) My example is I know 2 ASD brothers …one is at Oxford ..the other is completely dependent on his parents for life and severely affected by his ASD. Thanks for this additional thought…very interesting and feels very likely to be worth looking into partly to de stigmatise and partly to gather more facts.

    2. Thank you, I couldn’t agree more. The Farmers are still putting the Hunters down, I’m afraid. Glad you could put this in such a positive light for those of us tired of being considered less than who we really are.

    3. Thank you Bhoff and others! I have two boys and a husband who have been diagnosed with ADHD and will share your thoughts with them. You’ve helped me defame my thinking.

  2. I appreciate the introductory explanation of observable brain function and drawing awareness to how ADHD will manifest differently for individuals. We are all individuals – not all “neurotypicals” are identical! This is important because I find people think they can recognize ADHD because of individual cases they’ve met and cross off others because they don’t fit that stereotype.

    However, I especially appreciate the comment above. While I have benefited greatly from this website, I have a problem with the underlying assumption that a certain population with a particular brain type is “disordered” and that we have a “deficit”. Any person put into an environment or particular job completely unsuited to his or her gifts and thinking capacities, will look disordered! Just put a brilliant engineer into a party of theatre artists or a financier into a room of theologians (not to strictly stereotype – there could be cross-over! :)) – but you get my drift. Part of the problem is the actual term and the 2 Ds in ADHD. Attention Difference HyperActive Drive, for instance, might be a neutral label.

    We all have challenges in certain environments – surround yourself with people to whom you are atypical and you’ll probably feel insecure and dysfunctional. Understanding our differences is crucial and this is why I’m so glad for the articles. It feels amazing to know there are others like me, and why I don’t “measure” up in certain areas and what I can do to overcome it for what my civilization today demands of me. Or why certain people will enjoy my personality and others will come away with a negative impression – and what I can do to accommodate and adapt when beneficial. What excesses I may have to moderate in certain circumstances and where I can just “take-off” and fly. Why certain types of pedagogical approaches will NOT help my highly intelligent son learn, without fearing he has a problem, and patience when he needs transitioning from one activity to another, and when what seem to be average parental demands send him for a complete tailspin.

    Understanding one another and ourselves is critical for self-growth and effective relating. Diagonising a large minority of our population as disabled is problematic.

  3. Effemerald (above)

    My brain certainly feels ‘disabled’ and ‘disordered’… haven’t found it to be a ‘blessing in disguise”.
    My brain feels like sludge, my thinking fogged, and decisions taxing.

    Perhaps my perspective comes from having ADD as opposed to ADHD. I am missing the “hyperactive component” that may be considered “beneficial” if focused in a constructive way (as you pointed out in your comment).

  4. Interesting article. This sheds a little more light on what I thought were unrelated aspects of my personality. I have ADD, I would say more of the inattentive variety, though I can see aspects of the other subtypes as well. But I also seem to have an issue with being in a state of hyperarousal–I often am easily startled and jump when I hear an unexpected sound. One of my colleague friends even jokingly likes to make me jump. It’s an annoying trait but I can’t do anything about it. I think this hyperarousal state is also responsible for my light sleep. I don’t often get into a very deep stage of sleep (also confirmed by my fitbit) and will be up all night when it storms while my wife sleeps right through it. I am shy and would like to be more outgoing, but I wouldn’t say I have an anxiety disorder. Never had a panic attack. Just wish I could tamp down this overexcitement part of my brain, while at the same time increase the motivation to get stuff done. At work I spend a lot of time surfing the internet (like right now) instead of focusing on my tasks, and even at home it seems to take me forever to get any home projects finished…

  5. Effemerald: “Attention Difference HyperActive Drive, for instance, might be a neutral label.”

    I love this! I do think the current label is unfortunate and inaccurate for many. As has already been well-established, many people with ADHD are able to hyperfocus on something that is interesting to them. If you parlay that “something” into a career field, then it is definitely not a deficit! I agree that to label different wiring as a disorder may not be accurate or fair to everyone. I think it’s entirely possible that we will see a re-labeling as science uncovers more about ADD and ADHD. Considering it’s believed that the prevalence of ADD and ADHD are higher than current numbers suggest, are these conditions really so a-typical after all? Only about 2% of the world’s population has green eyes, yet no one ever calls green-eyed people “a-typical” or suggests that it’s a disorder.

  6. Having been diagnosed as ADHD In 2018 my mind went into overdrive my research of ADHD led me to see not only just how abundant undiagnosed ADHD is but also how it vastly differs from person to person. My X partner and I were like chalk and cheese he kept everything together he was so able and yet I could see he too was totally ADHD confirmed last year with his diagnosis.

  7. I’m dismayed that after all this time that there is still no ‘brain stimulation’ treatment for the “breakdown in the connectivity, the communication networks, and an immaturity in these networks” mentioned in this article, that plagues anyone with ADHD.

    In the same way that people who’ve experienced a stroke find their brain starts makes fresh neural connections around the stroke site – re-routing in order to repair things like speech and movement to pre-morbid functioning…

    I wonder why the ADHD brain cannot be stimulated in such a way to either rediscover these faulty or broken connections, strengthen or even forge them for the first time?

    Does anyone know of any research investigating this avenue?

    In recent years I’ve been very encouraged by the work of Professor Robin Carhart-Harris of the Psychedelic Research Unit (PRU) at Imperial College, London. They are doing extraordinary things in the the field of treatment-resistant depression, PTSD, morbidity fear in the terminally ill, alcohol dependence, and many more exciting innovative clinical trials.

    The benefit of introducing psychedelics *alongside* therapy has been shown to significantly increase number of new neural connections and traffic therein, giving patients not only extraordinary new insight into their condition, but also offering many participants with Major Depressive Disorder, a pressing reset experience, reported by many candidates in Imperial’s (and John Hopkins who they sometimes partner with) trials.

    The PRU is now adding trials for patients with Anorexia Nervosa, and other conditions.

    I can’t help but wonder who – if anyone – has considered what psychedelic treatment may offer those with ADHD – particularly in the area of forging new neural networks. It seems too interesting a possibility to ignore.

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