Mixing Imipramine and Stimulants


"Imipramine didn't affect my son's ADHD, but it helped him stop wetting the bed. Can we keep him on this in addition to giving him the stimulant his doctor wants him to try?"

Dr. Larry Silver specializes in treating children with attention deficit disorder (ADHD).

Imipramine enables the bladder to hold more urine at night. Often, you can discontinue imipramine after three months or so, and the bladder control will continue. If your son hasn't reached this point, it should be all right to continue the imipramine at night while your son takes a stimulant during the day. Ask your doctor about timing and doses.

Larry Silver, M.D., is clinical professor of psychiatry at Georgetown Medical Center in Washington, D.C. and director of training in child and adolescent psychiatry at Georgetown University School of Medicine. He is a former acting director and deputy director of the National Institute of Mental Health, as well as the author of Dr. Larry Silver's Advice to Parents on AD/HD and The Misunderstood Child: Understanding and Coping with Your Child's Learning Disabilities.
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